By Mary J. Laughlin, Hillard M. Lazarus
Across the world famous physicians and researchers assessment either the fundamentals of allogeneic stem mobilephone transplantation and up to date advances within the box, fairly as they relate to antitumor results and graft-versus-host ailment in addition they offer special decision-tree analyses to steer clinicians in making a choice on and handling their allogeneic transplant sufferers. The concepts mentioned conceal quite a few parts, starting from stem mobilephone mobilization in general donors, to symptoms for allogeneic transplantation except hematologic malignancies, to using nonmyeloablative conditioning regimens. The authors additionally discover new advancements within the optimum collection of unrelated allogeneic grafts (e.g., matched unrelated donor, in part mismatched friend, or umbilical twine blood), the use allogeneic peripheral blood stem mobilephone vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.
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Extra info for Allogeneic Stem Cell Transplantation (Current Clinical Oncology)
Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. N Engl J Med 1995;332:217–223. 21. Cassileth PA, Harrington DP, Appelbaum FR, et al. Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission. N Engl J Med 1998;339:1649–1656. 22. Bensinger W, Martin P, Storer B, et al. Transplantation of bone marrow as compared with peripheral blood cells from HLA-identical relatives in patients with hematologic malignancies.
Andersson BS, Kashyap A, Gian V, et al. Conditioning therapy with intravenous busulfan and cyclophosphamide (IV BuCy2) for hematologic malignancies prior to allogeneic stem cell transplantation: a phase II study. Biol Blood Marrow Transplant 2002;3:145–154. 72. Deeg HJ, Shulman HM, Anderson JE, et al. Allogeneic and syngeneic marrow transplantation for myelodysplastic syndrome in patients 55 to 66 years of age. Blood 2000;95:1188–1194. 28 Part II / Disease Indications: Allogeneic Transplantation Chapter 3 / Stem Cell Transplantation for ALL 3 29 Allogeneic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia Partow Kebriaei, MD and Wendy Stock, MD CONTENTS INTRODUCTION PROGNOSTIC FACTORS IN ADULT ALL ALLOGENEIC TRANSPLANTATION FOR HIGH-RISK ALL DURING FIRST CR ALLOGENEIC TRANPLANTATION BEYOND CR1 USING HLA-IDENTIFIED SIBLING DONORS PRIMARY REFRACTORY ALL PHILADELPHIA CHROMOSOME-POSITIVE ALL FACTORS INFLUENCING TRANSPLANT OUTCOME LONG-TERM COMPLICATIONS OF ALLOGENEIC TRANSPLANTATION NOVEL TRANSPLANT APPROACHES REFERENCES 1.
ALLOGENEIC TRANSPLANTATION AND MDS Because MDS is not curable with conventional treatment, feasibility studies of allogeneic transplantation began in the 1980s. Reports from several groups showed that the disease could be cured by allogeneic BMT (54,55). 20 Part II / Disease Indications: Allogeneic Transplantation Fig. 2. Proposed algorithm for treatment of adults diagnosed with AML based primarily on cytogenetic analysis of the patients’ leukemia at the time of diagnosis. CR, complete remission; PR, partial remission; IF, induction failure; ALLOBMT, allogeneic bone marrow transplantation; AUTOBMT, autologous bone marrow transplantation; MUD, matched unrelated donor.
Allogeneic Stem Cell Transplantation (Current Clinical Oncology) by Mary J. Laughlin, Hillard M. Lazarus