Read e-book online AIDS Vaccine Research PDF

By Flossie Wong-Staal, Robert C. Gallo

ISBN-10: 0585403627

ISBN-13: 9780585403625

ISBN-10: 0824706455

ISBN-13: 9780824706456

This reference describes the newest advances within the improvement and layout of an HIV preventive vaccine-detailing the pathogenesis and genetic variability of HIV an infection for the development of molecular and healing innovations to lessen the development and transmission of AIDS. With contributions by way of universally well-known gurus within the box, AIDS Vaccine study discusses

  • major hindrances within the identity of a preventive vaccine
  • the function of innate immunity in administration of HIV an infection
  • the effect of hugely lively antiretroviral remedy (HAART) on AIDS learn
  • the production of an efficient mucosal DNA vaccine
  • the influence of the AIDS epidemic on constructing international locations delivering approximately 2000 modern references to facilitate extra examine, AIDS Vaccine study is a well timed handbook compatible for immunologists, virologists, pathologists, epidemiologists, pharmacologists, microbiologists, hematologists, hepatologists, AIDS researchers, and upper-level undergraduate and graduate scholars in those disciplines.
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    Cytokines that enhance viral replication (ϩ), inhibit viral replication (Ϫ), and enhance or inhibit viral replication depending upon the conditions (ϩ/Ϫ) are shown. that have been reported to upregulate HIV replication in vitro include IL-1β, IL-2, IL-3, IL-6, IL-7, IL-12, IL-15, IL-18, TNF-α, TNF-β, and the colony-stimulating factors (CSF) macrophage (M)–CSF and granulocyte-macrophage (GM)–CSF (reviewed in Ref. 283; see also Refs. 308–313). IFN-α, IFN-β, and IL-16 (275,314,315) are primarily suppressors of HIV production, whereas other cytokines, such as IL-4 (316,317), IL-10 (318–321), IL-13 (316), IFN-γ (322,323), Immunopathogenesis of HIV Infection 29 and TGF-β (324,325), reduce or enhance viral replication depending on the infected cell type and the culture conditions.

    A. Axel. 1986. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47:333–348. 5. A. Berger. 1995. Fusogenic selectivity of the envelope glycoprotein is a major determinant of human immunodeficiency virus type 1 tropism for CD4ϩ T-cell lines vs. primary macrophages. Proc Natl Acad Sci USA 92:9004–9008. 6. C. A. Berger. 1996. Cell type-specific fusion Immunopathogenesis of HIV Infection 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 41 cofactors determine human immunodeficiency virus type 1 tropism for Tcell lines versus primary macrophages.

    Science 225:59–63. 3. , E. Champagne, S. Chamaret, J. Gruest, D. Guetard, T. -C. Gluckman, L. Montagnier. 1984. T-lymphocyte T4 molecule behaves as receptor for human retrovirus LAV. Nature 312:767–768. 4. G. S. R. A. A. Axel. 1986. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47:333–348. 5. A. Berger. 1995. Fusogenic selectivity of the envelope glycoprotein is a major determinant of human immunodeficiency virus type 1 tropism for CD4ϩ T-cell lines vs.

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    AIDS Vaccine Research by Flossie Wong-Staal, Robert C. Gallo


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