By Ali S. Faqi (Auth.)
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Additional resources for A Comprehensive Guide to Toxicology in Preclinical Drug Development
Central role of mitochondria in drug-induced liver injury. Drug Metab Rev 2012;44:34e87.  Jaeschke H, McGill MR, Ramachandran A. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev 2012;44:88e106.  Ju C. Preface to the drug-induced liver injury special issue. Drug Metab Rev 2012;44:1e4.  Rodriques DA. Drug-Drug Interaction: Drugs and the Pharmaceutical Sciences, vol. 116. NY: Marcel Dekker; 2002.
Because Eq. 32) is the summation of all molecules introduced into the body or the total dose, MRT expressed in this manner is the average time that a single molecule of the dose will spend in the body. Exposure: Cmax and AUC The parameters Cmax and AUC are both measures of a compound’s in vivo exposure . In toxicokinetics, an important endpoint is the estimation of exposure and AUC is routinely used to estimate safety margins that are critical to projecting the starting human dose in Phase I clinical studies.
On the other hand, drugs also are used for acute indications such as a headache or fever, in which case the patient may be dosed with one or a few doses of acetaminophen or ibuprofen. Whether a drug is taken chronically or acutely, pharmacokineticists concern themselves with how much and how often the drug can be administered to achieve the desired therapeutic effect. Variables or considerations such as body weight, age, renal function, and concomitant medications are a few of the important variables involved in determining an efficacious dose and dose regimen.
A Comprehensive Guide to Toxicology in Preclinical Drug Development by Ali S. Faqi (Auth.)